Faculty of Nursing and Midwifery
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Browsing Faculty of Nursing and Midwifery by Subject "Adolescents"
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Item Factors Associated with Utilization of HIV Testing Services among Adolescents Aged 10-19 Years in Lira District, Northern Uganda: A Cross-Sectional Study(Hindawi BioMed Research International, 2021-08-12) Benyumiza, Deo; Amongin, Joan Fidelia; Ochaba, Isaac; Adupa, Morish; Abuch, Naume; Banula, Constance Babirye; Udho, SamsonBackground. HIV testing remains a problem among adolescents in low- and middle-income countries, and yet, HIV testing is a cornerstone in the fight against HIV. However, there is scanty literature on the utilization of HIV testing services by adolescents especially in rural settings. This study is aimed at determining the uptake of HIV testing services and associated factors among adolescents aged 10-19 years in Lira District, Northern Uganda. Methods. This was a cross-sectional study done among 277 randomly selected adolescents aged 10-19 years attending outpatient clinics in Pentecostal Assembly of God (PAG) Mission Hospital, Ngetta Health Center III, and Boroboro Health Center III. Data were collected using an interviewer-administered structured questionnaire. Data collected included sociodemographic characteristics, history of test and receipt of HIV results in the last three months, and facility-related factors affecting uptake of HIV testing services. Data analysis consisted of descriptive statistics, cross-tabulations, and logistic regression at a 95% level of significance in SPSS version 25. Results. The uptake of HIV testing services was 43% (119/277) among the study participants. Adolescents who had completed primary education (aOR: 5.47; 95% CI: 1.07-28.15; ), are employed (aOR: 2.77; 95% CI: 1.16-6.60; ), had used a condom in the last sexual intercourse (aOR: 4.46; 95% CI: 1.78-11.15; ), and are involved in HIV testing outreaches (cOR: 10.86; 95% CI: 3.81-30.93; ) were more likely to uptake HIV testing services compared to those who had tertiary education, are unemployed, had never used a condom, and are not involved in HIV testing outreaches. Conclusion. Utilization of HIV testing services by adolescents aged 10-19 in Lira District, Northern Uganda, is generally low. The Ministry of Health should strengthen HIV testing services targeting adolescents to increase uptake of HIV testing services.Item Immunogenicity of bivalent HPV vaccine among partially vaccinatedyoung adolescent girls in Uganda(Elsevier Ltd., 2014) LaMontagne, D. Scott; Mugisha, Emmanuel; Pan, Yuanji; Kumakech, Edward; Ssemaganda, Aloysius; Kemp, Troy J.; Cover, Jane; Pinto, Ligia A.; Safaeian, MahboobehBackground: Investigations of vaccine efficacy and immunogenicity for adult females receiving fewerthan three doses of human papillomavirus (HPV) vaccine have suggested protection against infection andprecancerous lesions. We investigated the immunogenicity of bivalent HPV vaccines among adolescentgirls from Uganda who received one, two, or three vaccine doses.Methods: Young girls vaccinated through a government program in Uganda were invited to participate.HPV16- and HPV18-specific antibodies were measured at ≥24 months after the last vaccine dose usingan enzyme linked immunoassay in girls who received one (n = 36), two (n = 145), or three (n = 195) doses.Results: Nearly all subjects (99%) were HPV16 and HPV18 seropositive at the time of blood-draw.Geometric mean antibody levels (GMTs) were: HPV161-dose= 230 EU/mL, HPV162-dose= 808 EU/mL,and HPV163-dose= 1607 EU/mL; HPV181-dose= 87 EU/mL, HPV182-dose= 270 EU/mL, andHPV183-dose= 296 EU/mL. The GMT ratio for 2:3 doses was 0.50 (HPV16) and 0.68 (HPV18) anddid not meet the non-inferiority criteria (i.e., lower bound of 97.5% confidence interval of the GMT ratiogreater than 0.50). The GMT ratio for 1:3 doses for HPV16 and HPV18 was inferior, but absolute GMTs forone dose were higher than adult women who received one dose (HPV16 = 124 EU/mL, HPV18 = 69 EU/mL)where efficacy has been demonstrated.Conclusions: Even though immunogenicity with less than three doses did not meet a priori non-inferioritythresholds, antibody levels measured ≥24 months after last dose were similar to those of adult womenwho have been followed for more than eight years for efficacy.