Antiplasmodial activity of extracts of selected medicinal plants used by local communities in western Uganda for treatment of malaria
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Date
2007
Journal Title
Journal ISSN
Volume Title
Publisher
African Journal of Ecology
Abstract
This study investigated the antiplasmodial activity of ten
medicinal plants used to treat malaria in Southwestern
Uganda. The study plants were Bothlioclines longpipes (Olive
and Hiern), N.E.Br., Toddalia asiatica (L.) Lam., Maesa
lanceolata Forssk., Indigofera emerginella steud. Ex A. Rich.,
Lantana trifolia L., Vernonia lasiopus O. Hoffm., Trimmeria
bakeri Gilg., Rhus natalensis Bernh. ex. Krauss Erythrophleum
pyrifolia and Conyza sp. Dry powdered plant material was
extracted by sequential cold maceration using petroleum
ether, chloroform and ethanol solvents respectively.
Extracts were subjected to in vitro antiplasmodial screening
against wild strains of Plasmodium falciparum using
the nitro-tetrazolium blue-based lactate dehydrogenase
assay. The chloroform extract of M. lanceolata (EC50
1.60 lg ml)1.), showed the highest antiplasmodial activity
followed by R. natalensis (EC50 1.80 lg ml)1). Other extracts
with significant activity were the chloroform leaf extract
of Bothriocline longipes (EC50 3.66 lg ml)1) and the petroleum
ether root extract of T. bakeri (EC50 3.955 lg ml)1).
Description
Keywords
Antimalarial, Plasmodium falciparum, Traditional medicine, Uganda
Citation
Katuura, E., Waako, P., Tabuti, J. R., Bukenya‐Ziraba, R., & Ogwal‐Okeng, J. (2007). Antiplasmodial activity of extracts of selected medicinal plants used by local communities in western Uganda for treatment of malaria. African Journal of Ecology, 45, 94-98.