WHO guidelines on fluid resuscitation in children: missing the FEAST data
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
Bmj
Abstract
The World Health Organization recommendations on
management of common childhood illnesses affect the lives of
millions of children admitted to hospital worldwide. Its latest
guidelines,1 released in May 2013, continue to recommend rapid
fluid resuscitation for septic shock, even though the only large
controlled trial of this treatment (Fluid Expansion as a
Supportive Treatment (FEAST) found that it increased the risk
of death in African children.2 A subsequent systematic review
of bolus resuscitation in children with shock resulting from
severe infection also did not support its use.3 Failure to take this
evidence into account is not consistent with WHO’s commitment
to systematically and transparently assess evidence using the
GRADE (Grading of Recommendations Assessment,
Development and Evaluation) process when producing
guidelines and could endanger the lives of children
Description
Keywords
resuscitation, WHO
Citation
Kiguli, S., Akech, S. O., Mtove, G., Opoka, R. O., Engoru, C., Olupot-Olupot, P., ... & Maitland, K. (2014). WHO guidelines on fluid resuscitation in children: missing the FEAST data. Bmj, 348.