WHO guidelines on fluid resuscitation in children : Authors’ reply to Southall
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
BMJ Publishing Group Ltd
Abstract
Southall made several points about our recent article.1 2
He suggests that “lethal hyperchloraemia” secondary to use of
normal saline in FEAST (for boluses or maintenance) resulted
in excess mortality. However, he did not comment on the key
finding of the trial—that the increased 48 hour mortality was
identical in both normal saline bolus (10.6%) and albumin bolus
(10.6%) arms compared with the no bolus control group (7.3%).3
Harm was shown for every age group, in every condition, at
each of the six hospitals, regardless of degree of acidosis,4 and
for all definitions of shock.5 Despite differences in physical
properties of albumin and saline, the timing of excess mortality
after administration was identical (Kaplan-Meier mortality
curves),3 making his hypothesis improbable.
Description
Keywords
Fluid resuscitation, Children
Citation
Kiguli, S... et al (2014). Authors’ reply to Southall. Bmj, 348.