Ogwal-Okeng, JasperObua, Celestino.Anokbonggo, William W.2020-10-022020-10-022003Ogwal-Okeng, J. W., Obua, C., & Anokbonggo, W. W. (2003). Acute toxicity effects of the methanolic extract of Fagara zanthoxyloides (Lam.) root-bark. African Health Sciences, 3(3), 124-126.https://hdl.handle.net/123456789/168Background: Fagara zanthoxyloides is a well known medicinal plant in Uganda. It is used extensively in malaria and other infections. However nothing is known about its toxicity. Objective: The objective of the study was to evaluate the acute toxicity of the methanolic extract of the root-bark of F. zanthoxyloides, in mice. Methods: Methanolic extract of the root-bark of the plant was administered orally to mice at various dose levels to determine the acute toxic effects and the median lethal dose (LD50) in mice. Results: The LD50 of the methanolic extract was found to be 5.0 g/Kg body weight within 95 % confidence limits. The mice showed signs of cerebral irritation before dying. Histopathological examinations of the viscera showed congestion and focal necrosis of the liver and renal tubules. Conclusion: It was concluded that the extract of F. zanthoxyloides is safe, however the cerebral mechanism that lead to the death of the mice need to be investigated further.enFagara zanthoxyloidesmedicinal plantstoxicityUgandaArticle