Kiguli, SarahAkech, Samuel OMtove, GeorgeOpoka, Robert OEngoru, CharlesOlupot-Olupot, PeterNyeko, RichardEvans, JenniferCrawley, JanePrevatt, NatalieReyburn, HughLevin, MichaelGeorge, Elizabeth CSouth, AnnabelleBabiker, Abdel GGibb, Diana MMaitland, Kathryn2021-07-292021-07-292014Kiguli, S... et al (2014). Authors’ reply to Southall. Bmj, 348.348:g1619https://hdl.handle.net/123456789/302Southall made several points about our recent article.1 2 He suggests that “lethal hyperchloraemia” secondary to use of normal saline in FEAST (for boluses or maintenance) resulted in excess mortality. However, he did not comment on the key finding of the trial—that the increased 48 hour mortality was identical in both normal saline bolus (10.6%) and albumin bolus (10.6%) arms compared with the no bolus control group (7.3%).3 Harm was shown for every age group, in every condition, at each of the six hospitals, regardless of degree of acidosis,4 and for all definitions of shock.5 Despite differences in physical properties of albumin and saline, the timing of excess mortality after administration was identical (Kaplan-Meier mortality curves),3 making his hypothesis improbable.enFluid resuscitationChildren