Sebisubi, Fred MusokeOdyek, OlwaAnokbonggo, William WilberforceOgwal-Okeng, JasperCarcache-Blanco, Esperanza J.Ma, CuiyingOrjala, JimmyTan, Ghee T.2020-10-022020-10-022010Sebisubi, F. M., Odyek, O., Anokbonggo, W. W., Ogwal-Okeng, J., Carcache-Blanco, E. J., Ma, C., ... & Tan, G. T. (2010). Antimalarial activity of Aspilia pruliseta, a medicinal plant from Uganda. Planta medica, 76(16), 1870.https://hdl.handle.net/123456789/170Aspilia prulisetaSchweinf. (Asteraceae) is a medicinal plant in-digenous to Uganda and the neighboring countries of East Africa.It has been used extensively by the rural population for the treat-ment of fevers and malaria. During the antimalarial evaluation ofthis plant, four nontoxic diterpenes were isolated that possessedmoderate activity against chloroquine-sensitive (D6) and chloro-quine-resistant (W2) clones ofPlasmodium falciparum, with IC50values ranging from 14 to 23 μM. These moderately active com-pounds included the previously undescribed diterpene,ent-15β-senecioyloxy-16,17-epoxy-kauran-18-oic acid that demonstrat-ed an IC50value of 23.4 μM against clone D6, but was devoid ofactivity against clone W2. Four additional diterpenes were ob-tained from the aerial parts ofA. pruliseta, but these known com-pounds were essentially inactive. The moderate activities of se-lect diterpenes ofA. prulisetacould account collectively for thehistorical and enduring use of this plant in traditional Africanmedicine.enMalariaPlasmodium falciparumAspilia prulisetaDiterpenesAsteraceae